So far no big changes. I have had 2 pimples pop out today. Nothing painful and one was more than ready to be popped. I am using the retinoid cream 2 nights a week to start off. My current skincare regimen is a 2% salicylic acid and lipo-hydroxy acid cleanser, salicylic toner, a 5.5% micronized benzoyl peroxide and micro-exfoliating lipo-hydroxy acid spot treatment and a 15 SPF moisturizer during the day. At night, sometimes I double cleanse with a gentle cleanser first, then the acne wash, a balancing toner, on nights I don’t use the retinoid cream and a nighttime moisturizer. I’ll be changing by face wash, not using the toner during the day, instead I’ll be using Niacinamide 2 times daily and a different moisturizer.